Preclinical Studies Shed Light on Individual Variation in Addiction Vulnerability

Studies shed light on sunscreen efficacy.

Sister studies aim to shed light on breast cancer risk.

later risk of breast cancer. A companion project begun in 2008, the Two Sister Study, focusing only on women younger than 50 years with breast cancer, has already yielded preliminary data on the use of fertility drugs and early-onset breast cancer. However, its fi ndings still await publication. Because the women in the Two Sister Study have been diagnosed with cancer, " we can do case – contro...

Stress and relapse to drug seeking: studies in laboratory animals shed light on mechanisms and sources of long-term vulnerability.

Relapse is a major characteristic of drug addiction disorders and remains the primary problem for treatment. Recently, there has been hope that these disorders may be amenable to pharmacological treatments that have successfully treated other psychopathological disorders. Pharmacological approaches to drug abuse have tended to be guided by the primary drug used by the individual, though substit...

Preclinical studies on comorbidity between depression and psychostimulant addiction.

Several clinical data indicate that depression is frequently comorbid with psychostimulant (cocaine, amphetamines) addiction. This short review summarizes preclinical results and observations showing how reward processes are modified in animal models of depression, and which depression-like effects are induced in experimental animals withdrawn from chronic treatment with psychostimulants.

Quantum dots shed light on diagnoses.

Featured article: Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, Nakayama A, Parker JA, Mihaljevic T, Laurence RG, Dor DM, Cohn LH, Bawendi MG, Frangioni JV. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol 2004;22:93–7. Near-infrared (NIR) (700 –2500 nm) in vivo imaging with semiconductor quantum dots (QDs) can offer nonradioactive extraction of me...